ARA-290-10mg

Description

ARA-290 (also known as Cibinetide / pyroglutamate helix B surface peptide) is a high-purity, research-grade synthetic nonapeptide (pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser) derived from the spatial conformation of the three-dimensional helix B domain of endogenous erythropoietin (EPO). Unlike native EPO, ARA-290 exhibits no binding affinity for the classical erythropoietin homodimer receptor (EPOR2) and therefore does not stimulate erythropoiesis, hematocrit elevation, or pro-thrombotic cascades. It is commonly examined in preclinical and in vitro investigations focused on tissue cytoprotection, neuroprotection, and peripheral nerve repair mechanisms.

In laboratory environments, ARA-290 functions as a selective agonist of the heteromeric Innate Repair Receptor (IRR), a complex composed of the erythropoietin receptor monomer and the beta common receptor subunit (EPOR/CD131). Activation of the IRR initiates downstream anti-inflammatory and anti-apoptotic signaling cascades, primarily via the inhibition of nuclear factor-kappa B (NF-κB) phosphorylation and the attenuation of pro-inflammatory cytokine production (including TNF-α, IL-1β, and IL-6). Researchers frequently utilize this compound to evaluate small-fiber axonal regeneration kinetics, Schwann cell survival dynamics, microvascular endothelial preservation, and neuropathic signaling pathways in chronic inflammatory and metabolic stress models. This compound is supplied in a lyophilised form suitable for controlled research applications.

Product Specifications:

• Quantity: 10mg Research vial format (as specified on order)
• Purity: Research-grade, verified via laboratory testing
• Form: Lyophilised peptide
• Storage: Store in a cool, dry environment away from direct light

Intended Use:

This product is intended exclusively for laboratory, academic, and controlled research purposes involving innate repair receptor (EPOR/CD131) binding kinetics, small-fiber neuroregenerative signaling, and selective anti-inflammatory cytoprotective pathway investigations.

Disclaimer:

All information provided is for scientific, educational, and reference purposes only. This product has not been evaluated or approved by any regulatory authority. It is not intended to diagnose, treat, cure, or prevent any disease, and must not be used for human or animal consumption. The purchaser assumes full responsibility for proper handling, storage, and lawful use in a research setting.

Terms of Sale:

By purchasing ARA-290 from TRUEBASE PEPTIDES, you confirm that you are a qualified professional, researcher, or institution with the expertise required to safely handle and study research compounds. TRUEBASE PEPTIDES shall not be held liable for misuse, improper handling, or any consequences arising from unauthorised application of this compound.