KPV-10mg

Description

KPV 10mg (Lys-Pro-Val) is a high-purity, research-grade synthetic C-terminal tripeptide fragment of endogenous alpha-melanocyte-stimulating hormone (α-MSH 11-13). It is commonly examined in preclinical and in vitro investigations focused on targeted anti-inflammatory signaling, mucosal epithelial homeostasis, and antimicrobial peptide mechanics. Unlike full-length α-MSH, KPV lacks melanocortin-1 receptor (MC1R) pigmentary agonist activity, allowing researchers to evaluate isolated immunomodulatory pathways without inducing melanogenesis.

In laboratory environments, KPV enters cells via peptide transporter 1 (PepT1) and exerts its primary biochemical effects through the selective inhibition of the nuclear factor-kappa B (NF-κB) transcription pathway. By attenuating the nuclear translocation of NF-κB p65 subunits, KPV downregulates the transcription and secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8. Researchers frequently utilize this compound to investigate intestinal mucosal barrier repair kinetics, colonic epithelial preservation in inflammatory bowel models, dermal wound remodeling, and host-defense mechanisms against microbial pathogens without systemic immunosuppression. This compound is supplied in a lyophilised form suitable for controlled research applications.

Product Specifications:

• Quantity: 10mg per vial
• Purity: Research-grade, verified via laboratory testing
• Form: Lyophilised peptide
• Storage: Store in a cool, dry environment away from direct light

Intended Use:

This product is intended exclusively for laboratory, academic, and controlled research purposes involving NF-κB signaling kinetics, PepT1 transport dynamics, mucosal barrier cytoprotection, and anti-inflammatory pathway investigations.

Disclaimer:

All information provided is for scientific, educational, and reference purposes only. This product has not been evaluated or approved by any regulatory authority. It is not intended to diagnose, treat, cure, or prevent any disease, and must not be used for human or animal consumption. The purchaser assumes full responsibility for proper handling, storage, and lawful use in a research setting.

Terms of Sale:

By purchasing KPV 10mg from TRUEBASE PEPTIDES, you confirm that you are a qualified professional, researcher, or institution with the expertise required to safely handle and study research compounds. TRUEBASE PEPTIDES shall not be held liable for misuse, improper handling, or any consequences arising from unauthorised application of this compound.